What Medicines And Foods Should Not Be Mixed With Alcohol

Drinking alcohol while taking medicine.
What are the worst alcohol combinations?

What not to mix with alcohol: Some substances and products combined with alcohol can lead to serious health problems and even death.


Studies show that it is dangerous to use alcohol with any drugs, as it changes their effect. However, in some cases, an adverse effect can be predicted.

Antibacterial drugs

The ban on mixing alcohol with antibiotics has long been an axiom that seems to require no proof. This rule applies to all substances that are used to combat microorganisms and parasites found in various tissues and internal organs of the person. These include antibiotics, sulfonamides, nitrofuran derivatives, metronidazole and anti-tuberculosis drugs.

Alcohol consumption while taking these drugs weakens or neutralizes the effect of the drugs. Alcohol in combination with individual substances may have more unpleasant consequences.

Nitrofurans and metronidazole

The enzyme alcohol dehydrogenase is responsible for alcohol processing in the body. Preparations of nitrofuran medication group (furazolidon, nitrofurantoin, furadonin, furatsilin, furagin, nifuroxazide) and metronidazole block its production, the body accumulates acetaldehyde – a product of intermediate oxidation. This leads to an disulfide reaction, which manifests itself as the heaviest hangover.


Antibiotics of the cephalosporins group (cefazolin, cephalexin, ceftolozane) inhibit alcohol oxidation, prolong intoxication and toxic effect of alcohol.

Anti-Tuberculosis drugs

Repeated use of alcohol increases the harmful effects of these medications on the liver.


Taking aspirin, amidopirin, analgine, butadione and other drugs of this group with alcohol can lead to intolerance of the medications. The combination of alcohol with paracetamol and similar antipyretic agents causes severe liver damage.

Cardiovascular system

The combined use of nitroglycerin, validol, joint, erinitis, nitrosorbide, verapamil and alcohol leads to a sharp drop in blood pressure, combined with dizziness and nausea.

As for antihypertensive drugs, in the first few hours alcohol stimulates their action through its ability to expand vessels. However, then, stimulation with ethanol of the nervous system will lead to a higher blood pressure.

Soothing and sleeping pills

Alcohol increases the effect of medications, as both alcohol and some medicine depress the central nervous system. This can lead to damage to the respiratory center in the brain, cardiac arrest and death.


Alcohol reduces blood glucose, which can lead to hypoglycemic seizures and coma if insulin is taken with Alcohol . At the same time, studies show that mainly diabetics are at risk.


Alcohol in combination with substances that prevent blood clotting – dicumarine, phenylamine and even aspirin – can lead to extensive bleeding into the internal organs, which may result in death.


Caffeine and other tonic substances have a stimulating effect on the nervous system, and alcohol is an oppressive one. Taken together, this mixture masks the real degree of intoxication, so a person drinks more alcohol than he can afford, which increases the load on the liver and other organs.

Among the side effects of a cocktail of alcohol and Stimulants are increased blood pressure, spasms of brain blood vessels, seizures, stroke and heart attack.


Pickled cucumbers and tomatoes are not such a good snack as it is commonly thought. Vinegar slows down the process of alcohol breakdown in the body, which increases the toxic effect on the liver and kidneys. Dehydration resulting from the slow processing of alcohol causes an additional blow to these organs.

Desserts and sweets

Not only cakes, pastries, sweets, but also fruit and berries with a high content of simple sugars can be problematic when mixed with Alcohol.

Alcohol has almost zero nutritional value, so the body breaks it down immediately. Sugar is a competition to alcohol in the processing queue, so breaking down alcohol slows down and the time of its toxic effects on the body increases. This can lead to poisoning.

One should not forget that alcohol is dangerous not only in special combinations, but also in itself. According to the World Health Organization, alcohol is the cause of 5.9% of global deaths and 5.1% of diseases and injuries. Therefore, drinking alcohol is a problem even in relatively safe combinations.


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